Metronomic Dosing Enhances the Anti-Angiogenic Effect of Epothilone B
نویسندگان
چکیده
منابع مشابه
Anti-tumor and anti-angiogenic effect of metronomic cyclic NGR-modified liposomes containing paclitaxel.
In the present study, we prepared NGR-modified sterically stabilized liposomes containing paclitaxel (NGR-SSL-PTX) in order to evaluate their potential targeting to aminopeptidase N receptors expressed on tumor endothelial cells and the tumor cell surface and its anti-angiogenic activity following metronomic administration. NGR-SSL-PTX was prepared by a thin-film hydration method. The in vitro ...
متن کاملThe Anti-Proliferative and Anti-Angiogenic Effect of the Methanol Extract from Brittle Star
Background: Anti-angiogenic therapy is a crucial step in cancer treatment. The discovery of new anti-angiogenic compounds from marine organisms has become an attractive concept in anti-cancer therapy. Because little data correlated to the pro- and anti-angiogenic efficacies of Ophiuroidea, which include brittle star, the current study was designed to explore the anti-angiogenic potential of bri...
متن کاملThe Anti-angiogenic Effects of Sparstolonin B
Sparstolonin B (SsnB) is a novel bioreactive compound isolated from Sparganium stoloniferum, an herb historically used in Traditional Chinese Medicine as an anti-tumor agent. SsnB has demonstrated anti-inflammatory properties, inhibiting Toll-like receptor mediated inflammation in isolated macrophages and in mice. Angiogenesis, the process of new capillary formation from existing blood vessels,...
متن کاملContinuous low-dose anti-angiogenic/ metronomic chemotherapy: from the research laboratory into the oncology clinic.
Continuous low-dose anti-angiogenic/ metronomic chemotherapy: from the research laboratory into the oncology clinic The words 'side effect' usually evoke a mixture of fear and anxiety in cancer patients receiving chemotherapy. But, as it turns out, not all side effects are necessarily harmful, or even undesirable. While the collateral damage inflicted upon the dividing bone marrow progenitors, ...
متن کاملMicroRNA-765 Enhances the Anti-Angiogenic Effect of CDDP via APE1 in Osteosarcoma
Human osteosarcoma (HOS) is the most common malignancy in children and adolescents and has a heterogeneous presentation and high mortality. Previous studies have shown that microRNAs contribute to RNA silencing and post-transcriptional regulation of gene expression. Here, we showed that significantly increased expression of miR-765 with or without CDDP (Cisplatin) down-regulates APE1 expression...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Surgical Research
سال: 2011
ISSN: 0022-4804
DOI: 10.1016/j.jss.2009.12.001